Allergen Levels

Large scale research has shown that all cats produce some feline allergen (Fel-d1).  Members of Siberian Research submitted data from hundreds of adult Siberians. The data on adult breeding Siberians was compiled on November, 2009.  All testing was performed by Indoor Biotechnologies laboratory in Virginia. 

Saliva tests were performed by inducing salivation using a bitter agent and collecting the saliva. Several tests were run on each cat to determine the accuracy of the tests and effect of different salivants.  

Metranitazole (Flagil) and Sulfa produced the most consistent results in the study.  The rate of incorrect tests with these materials was 20% in adult cats, and 40% in kittens under the age of nine months. * A more advanced and accurate method of testing is available to breeders through 

Results using Drontal and Citric Acid to induce saliva were highly irregular and discarded from the study. Studies by NIH have shown that citric acid alters the flow rates of enzymes and proteins in human saliva. funded studies using citric acid with Siberians, and found it directly interfered with Fel d1 tests. Citric Acid is one of the most common salivant for dog allergens, with some company selling pre-loaded swabs. Due to biological interactions, it not suitable for testing Fel d-1.

About 50% of Siberians were found to have lower Fel d1 levels than normal cats.  Under 15% of Siberians produced very low levels of the allergen, and could safely be placed in homes with severe or dangerous reactions to cats.  Low allergen matings produced more offspring with reduced lower levels of Fel-d1, though some kittens from most low-allergen matings still had normal levels of Fel d1.

Some isolated tests of Siberians show individual cats below 0.2 mcg or over 16 mcg.  When these tests were repeated, they were always inconsistent and have been removed from the following tables.

The following chart was developed for SRI, and may be copied and used freely by Siberian Breeders.

Copyrighted more detailed reference charts are available through

Allergen Levels in Mature Breeding Siberians.

Saliva test ranges in Siberians: 0.08 mcg - 32 mcg
Very low saliva levels:         0.2 mcg - 1.0 mcg
Low saliva allergen level:    1.0 mcg - 2.0 mcg
Med. saliva allergen level:   2.0 mcg - 4.0 mcg
High saliva allergen level:   4.0 mcg - 16 mcg

Fur test ranges in Siberians:  5 mcg - 1300 mcg
Very low fur levels:              10 mcg - 50 mcg
Low fur allergen levels:        50 mcg - 100 mcg   
Med. fur allergen level:        100 mcg - 200 mcg
High fur allergen levels        200 mcg - 600 mcg

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Information Provided by Siberian Research Inc.

 Tom Lundberg 2005